CHEM 325

ORGANIC STRUCTURAL METHODS

COURSE OUTLINE

Dr. D. Klapstein Office: 3027 Physical Sciences

Tel: 867-2469 e-mail: dklapste@stfx.ca

 

TEXT: Introduction to Spectroscopy, 5th Edition, by Pavia, Lampman, Kriz, and Vyvyan, Brooks/Cole, 2015.

 

COURSE DESCRIPTION: Spectroscopy plays a central role in determining the structure of molecules. No substance can be characterized without calling on some sort of spectroscopic technique; often, a combination of several techniques are employed to deduce the numbers of atoms, their bonding, and their spatial arrangement. This course will examine methods used in structural analysis in modern organic chemistry. Each section will include a minimum discussion of the instrumentation in order to understand the principles, scope, and limitations of the technique but the emphasis will be placed on how spectral interpretation can provide information on compound identification and structure, including stereochemistry. Each section will involve problem sets, and as the course progresses, integrative problems will be used to demonstrate the complementarity of the methods.

 

 

 

COURSE WEB SITE: http://people.stfx.ca/dklapste/Chem325/home.htm

 

TUTORIAL: WEDNESDAY, 7:00 9:00 PM (+/-), location TBA

 

 

 

TOPICS:

 

Elemental analysis (0.5 lectures)

 

Reading the formula: structural predictions (1 lecture)

 

Vibrational Spectroscopy (7 lectures)

Intro and experimental methods

Group frequencies

Comparison of infrared and Raman

Analysis of common functional groups

Correlation charts and tables

How to approach analysis of a spectrum

 

Mass Spectrometry (6 lectures)

Ionization and mass analysis

Fragmentation and ion chemistry

Isotopic analysis

Fragmentation and structural analysis

Correlation charts and tables

How to approach analysis of a spectrum

Nuclear Magnetic Resonance Spectroscopy (13 lectures)

Intro and experimental methods (CW to FT)

The chemical shift

The coupling constant: homonuclear and heteronuclear

Carbon-13 aspects

Relaxation times

The Nuclear Overhauser Effect

Phase cycling and composite pulses

Two-dimensional NMR

Other NMR-active nuclei

Spectral predictions and databases

 

 

Electron Spin Resonance Spectroscopy (2 lectures)

Intro and experimental methods

Generation and properties of radicals

Coupling constants

 

Electronic Absorption and Chiroptical Spectroscopy (4 lectures)

Intro and experimental methods

UV-Vis, Polarimetry, CD, and ORD

 

 

 

 

Marking Scheme:

 

In-term exams (2) 40%

Assignments/Quizzes 25%

Final Exam 35%

 

 

 

 

Academic Integrity

 

Please review section 3.8 of the Academic Calendar. A more thorough treatment can be found at this link:

http://sites.stfx.ca/registrars_office/academic_integrity